Contrave (naltrexone/bupropion) vs Foundayo (orforglipron)
Contrave is the better choice of the two, winning on entry price; the halfrx scores are tied at 6.3.
Computed from the stored fields, so it moves when a price does. Nothing here is written by hand or by a model.
Which is cheaper, Contrave (naltrexone/bupropion) or Foundayo (orforglipron)?
Contrave (naltrexone/bupropion) is $99 a month all-in, read from its own page on 2026-09-22; Foundayo (orforglipron) is $149–$349, read from its own page on 2026-09-12. At the maintenance dose the gap is $200 a month, which is $2,400 across a year, counting 12 fills. Trial weight loss was 5.4% against 11.1%, from separate trials with different populations, so the gap is not a measured difference between the two. Every axis below is computed from stored fields rather than written by hand, so the comparison moves when a price does. They were last checked on 2026-09-22 and 2026-09-12. Neither carries an FTC action, a state action, a BBB F grade or an FDA warning letter. The published formula scores them 6.3 and 6.3 out of 10, arithmetic over the same stored fields rather than an editor's preference.
Head to head
| What decides it | Contrave $99/mo | Foundayo $149–$349/mo |
|---|---|---|
| Entry priceContrave (naltrexone/bupropion) is $50/mo cheaper to start — $99 against $149. | ✓ better here | — |
| Regulatory and complaint riskNeither carries a lawsuit, an FDA warning letter or a supply-risk flag. | tied | tied |
| Average weight loss in trialsContrave (naltrexone/bupropion) reports 5.4% and Foundayo (orforglipron) 11.1%, each from its own trial. They were not compared against each other, and the populations, durations and endpoints differ, so the higher number is not a better result — it is a different study. | not comparable | not comparable |
What the trials, the titration and a year actually say
| Axis | Contrave | Foundayo |
|---|---|---|
| Mean weight loss in the cited trial | 5.4% | 11.1% |
| The trial that figure comes from | COR-I on the label, 56 weeks: 5.4% mean weight loss on 32 mg/360 mg against 1.3% on placebo, intention-to-treat. | ATTAIN-1, Trial 1 on the label, 72 weeks: 11.1% mean weight loss at 17.2 mg against 2.1% on placebo, intention-to-treat. |
| Maintenance dose | 2 tablets twice a day | 5.5 mg, 9 mg, 14.5 mg or 17.2 mg daily |
| Earliest week you reach it | week 4 | week 9 |
| Year one at the published price of every step | $1,188 | $3,188 |
Trial percentages are quoted from the label or the named trial beside them. They are not a head-to-head result: different populations, different durations, different endpoints. That is why the comparison above scores this axis as not comparable rather than awarding it to the higher number. The year-one figures walk each titration step at its published price — Contrave has one price at every dose, so there is no step to walk — and count the twelve 30-day bottles a year holds. The full arithmetic is published.
Read the price gap carefully: these two are not the same purchase
- These are different molecules — naltrexone and bupropion against orforglipron — so this is a comparison of two treatments, not of two prices for one.
- Against every medication on this site with a verified maintenance price, Contrave (naltrexone/bupropion) is the 2nd cheapest of 9 and Foundayo (orforglipron) the 3rd — the cheapest of them all is $75.
Contrave (naltrexone/bupropion)
Pros
- +$99 a month direct from the manufacturer's CurAccess program — below every branded GLP-1 on this site, and tied with the cheapest compounded route.[1]
- +Oral, no injections, no refrigeration, no titration involving needles.[2]
- +Works on appetite and reward pathways rather than gut hormones, so it is an option for people who cannot tolerate GLP-1 side effects.[3]
- +The bupropion component may help if you also want to stop smoking or have low mood.[3]
Cons
- −5.4% mean weight loss at 56 weeks in COR-I, the trial on its label — about a third of semaglutide and a quarter of tirzepatide.[4]
- −Boxed warning for suicidal thoughts and behaviors from the bupropion component.[3]
- −Contraindicated with uncontrolled hypertension, seizure disorders and opioid use — the opioid interaction matters, because naltrexone blocks opioid pain relief in an emergency.[3]
- −Placebo arm lost 1.3%, so the drug-attributable effect is about four points rather than the headline figure.[4]
Foundayo (orforglipron)
Pros
- +A daily pill with no injection, no needles and no refrigeration — unlike semaglutide pills it is a small molecule, so there are no food-and-water timing rules to follow.[3]
- +$149 a month at the entry dose through LillyDirect — the lowest self-pay price for a branded GLP-1 on this site, matched only by the Wegovy pill's first month.[4]
- +11.1% mean weight loss over 72 weeks in ATTAIN-1, intention-to-treat — below the Wegovy tablet's 13.6%, and well above the older oral options.[2]
- +Being a small molecule, it is manufactured chemically rather than biologically — supply scales in a way peptide injectables cannot.[3]
- +Commercially insured with coverage, Lilly's card can bring it to as little as $25 a month.[1]
Cons
- −Approved 1 April 2026, so real-world safety data outside trials is still thin compared with semaglutide's years of use.[2]
- −$649 list price if you have no coverage and do not use the LillyDirect self-pay channel.[4]
- −Weight loss trails tirzepatide injection, which reaches roughly 20%+ in its pivotal trials.[2]
- −Maintenance doses hold their $299 price only while you refill within 45 days; lapse and they are $349.[1]
Comparisons are computed from the fields on each card, not written by hand or by a model, so they change when the data does. Information only, not medical advice. halfrx may earn a commission from some links, which never changes what a comparison says.
Everything on Contrave
- Contrave price and terms →
- What is Contrave? →
- Contrave cost without insurance →
- Alternatives to Contrave →
- Contrave coupons and savings cards →
- Contrave Home Delivery →
- Contrave side effects →
- Does Contrave make you feel sick? →
- Does Contrave cause constipation? →
- Does Contrave cause diarrhea? →
- Does Contrave make you throw up? →
- Does Contrave make you dizzy? →
- Does Contrave cause headaches? →
- Does Contrave keep you awake? →
- Does Contrave cause dry mouth? →
- Contrave dose schedule →
- How to take Contrave →
- How long Contrave takes to work →
- Which labels record what happens when you stop →
- Hair loss: which of the labels name it →
- Alcohol: what the labels say, and what they do not →
Everything on Foundayo
- Foundayo price and terms →
- What is Foundayo? →
- Foundayo cost without insurance →
- Alternatives to Foundayo →
- Foundayo coupons and savings cards →
- Foundayo Self Pay Journey Program →
- Foundayo side effects →
- Does Foundayo make you feel sick? →
- Does Foundayo make you tired? →
- Does Foundayo cause constipation? →
- Does Foundayo cause diarrhea? →
- Does Foundayo make you throw up? →
- Does Foundayo cause hair loss? →
- Does Foundayo cause stomach pain? →
- Does Foundayo cause indigestion? →
- Does Foundayo cause acid reflux? →
- Does Foundayo make you burp? →
- Does Foundayo cause bloating? →
- Does Foundayo cause headaches? →
- Foundayo dose schedule →
- Can you stay on a lower dose of Foundayo? →
- How to take Foundayo →
- How long Foundayo takes to work →
- Which labels record what happens when you stop →
- Hair loss: which of the labels name it →
- Alcohol: what the labels say, and what they do not →
- orforglipron at LillyDirect: the price →
- orforglipron: every product and price →
- LillyDirect: the seller →
Contrave against Foundayo, answered
- Is Contrave or Foundayo better for weight loss?
- Contrave reports 5.4% average weight loss and Foundayo 11.1%, each from its own trial. The two were not compared against each other, so the higher figure is not a result of a head-to-head and this page does not present it as one. What is comparable is what each costs, below.
- Which is cheaper, Contrave or Foundayo?
- Contrave, at $99 a month against $299 — a difference of $200 a month, or $2,400 over a year counting the twelve 30-day bottles a year holds. Both figures are the maintenance price rather than an introductory rate.
- Can you switch between Contrave and Foundayo?
- They are different molecules, so this is a change of medication rather than of brand, and the one you move to is started on its own dosing schedule.