Does Contrave cause constipation?
Bottom line
Yes. Constipation is listed among the common adverse reactions on Contrave's own FDA label, published 2025-11-17. It clusters in the days after each dose increase. Contrave steps up on a published schedule that reaches the maintenance dose at week 4, so the pattern most people see is a few rough days after each step and a settling in between — not one long stretch. Once you are at 2 tablets twice a day and no longer stepping up, the trigger stops recurring.
Last updated 2025-11-17 — the FDA label this page quotes
Does Contrave cause constipation?
Yes, and it is on the label rather than only in reports: constipation appears among the common adverse reactions in Contrave's FDA prescribing information, published 2025-11-17. Listed means it was seen often enough in the trials to be printed, not that everyone gets it. The same slowed gut transit that produces the fullness produces constipation at the other end. Eating much less compounds it: less food means less fibre and less fluid, and both are what keep things moving. It clusters in the days after each dose increase. Contrave steps up on a published schedule that reaches the maintenance dose at week 4, so the pattern most people see is a few rough days after each step and a settling in between — not one long stretch. Once you are at 2 tablets twice a day and no longer stepping up, the trigger stops recurring. What helps, in the order worth trying: fluid first. It is the most common deficit and the easiest to fix; fibre added gradually rather than all at once, which otherwise trades constipation for bloating; movement, which does more for gut transit than most supplements; asking the prescriber about a stool softener or an osmotic laxative before reaching for a stimulant one. It stops being ordinary at a specific line: no bowel movement for several days with abdominal pain, distension or vomiting. That combination needs assessment rather than another laxative.
Why Contrave does this
The same slowed gut transit that produces the fullness produces constipation at the other end. Eating much less compounds it: less food means less fibre and less fluid, and both are what keep things moving.
When it happens, against Contrave's own schedule
Tablets, twice a day. Each row is a step up, and the days after each one are when this tends to arrive.
| Weeks | Dose |
|---|---|
| Week 1 | 1 tablet in the morning |
| Week 2 | 1 morning, 1 evening |
| Week 3 | 2 morning, 1 evening |
| Week 4 and on | 2 morning, 2 evening |
What actually helps
- 1Fluid first. It is the most common deficit and the easiest to fix.
- 2Fibre added gradually rather than all at once, which otherwise trades constipation for bloating.
- 3Movement, which does more for gut transit than most supplements.
- 4Asking the prescriber about a stool softener or an osmotic laxative before reaching for a stimulant one.
This is not a GLP-1: it is naltrexone plus bupropion, and its risks are neurological and cardiovascular rather than gastrointestinal. Anyone taking an opioid, including buprenorphine for addiction, cannot take it at all.
When to stop reading and call someone
No bowel movement for several days with abdominal pain, distension or vomiting. That combination needs assessment rather than another laxative.
Separately, Contrave carries a boxed warning. Bupropion raises the risk of suicidal thoughts and behaviour in children, adolescents and young adults. The label carries that as a boxed warning and tells prescribers to watch for mood changes, particularly in the first months and after any dose change.
The other 3 common reactions on Contrave's label
If you are thinking of switching
Constipation is on the label of most drugs in this class, so a switch is not a reliable way out of it. What a switch does change is what you pay, and Contrave is $99 a month at the maintenance dose here.
Every alternative to Contrave, with each one's verified price and the date it was read →
Contrave and constipation, answered
- Does Contrave cause constipation?
- Yes — constipation is listed among the common adverse reactions on Contrave's FDA prescribing information, published 2025-11-17. Listed means it was seen often enough in the trials to be printed, not that it happens to everyone.
- How long does Contrave constipation last?
- It clusters in the days after each dose increase. Contrave steps up on a published schedule that reaches the maintenance dose at week 4, so the pattern most people see is a few rough days after each step and a settling in between — not one long stretch. Once you are at 2 tablets twice a day and no longer stepping up, the trigger stops recurring.
- What helps with constipation on Contrave?
- Fluid first. It is the most common deficit and the easiest to fix. Fibre added gradually rather than all at once, which otherwise trades constipation for bloating. Movement, which does more for gut transit than most supplements. Asking the prescriber about a stool softener or an osmotic laxative before reaching for a stimulant one.
- When is constipation on Contrave serious?
- No bowel movement for several days with abdominal pain, distension or vomiting. That combination needs assessment rather than another laxative.
- Would switching drugs help?
- Possibly, and possibly not — constipation is listed on the labels of most drugs in this class, so a switch is not a way out of it by default. What a switch does change is the price: every verified route to each molecule is priced on this site with the date each figure was read.
Everything above is read from FDA prescribing information for CONTRAVE, published 2025-11-17. Information only, not medical advice — a symptom that worries you is a call to your prescriber, not a search result.