Does Contrave cause constipation?
Bottom line
Yes. Constipation is listed among the common adverse reactions on Contrave's own FDA label, published 2025-11-17. It is worst in the days after each dose increase, and Contrave reaches its maintenance dose at week 4.
No clinician has reviewed this page. Label and trial statements are quoted from the FDA label or the trial cited beside them. General guidance is marked as such, and every price carries the date it was verified. That is sourcing, not medical review. What we do and do not check · Who checked the price
Last updated 2025-11-17 — the FDA label this page quotes. Read and dated by Alex Seot.
Does Contrave cause constipation?
Yes, and it is on the label rather than only in reports: constipation appears among the common adverse reactions in Contrave's FDA prescribing information, published 2025-11-17. Listed means it was seen often enough in the trials to be printed, not that it happens to everyone. Contrave is not a GLP-1 and does not slow gut transit the way those drugs do; its label lists constipation among the common reactions without naming a mechanism. Eating much less compounds it on any weight-loss drug: less food means less fiber and less fluid, and both are what keep things moving. It clusters in the days after each dose increase. Contrave steps up on a published schedule that reaches the maintenance dose at week 4. Most people see a few rough days after each step and a settling in between, not one long stretch. Once you are at 2 tablets twice a day and no longer stepping up, the trigger stops recurring. What helps first: fluid first. It is the most common deficit and the easiest to fix. It stops being ordinary at a specific line: no bowel movement for several days with abdominal pain, distension or vomiting. That combination needs assessment rather than another laxative.
How long does Contrave constipation last?
Tablets, twice a day. Each row is a step up, and the days after each one are when this tends to arrive.
| Weeks | Dose |
|---|---|
| Week 1 | 1 tablet in the morning |
| Week 2 | 1 morning, 1 evening |
| Week 3 | 2 morning, 1 evening |
| Week 4 and on | 2 morning, 2 evening |
What helps with constipation on Contrave?
- 1Fluid first. It is the most common deficit and the easiest to fix.
- 2Fiber added gradually rather than all at once, which otherwise trades constipation for bloating.
- 3Movement, which does more for gut transit than most supplements.
- 4Asking the prescriber about a stool softener or an osmotic laxative before reaching for a stimulant one.
This is not a GLP-1: it is naltrexone plus bupropion, and its boxed warning and main serious risks concern mood, seizures, opioid use and blood pressure. Its most common side effect is still nausea: in the trials 24% stopped because of an adverse event, against 12% on placebo, and nausea was the most common reason, at 6.3%. Anyone on long-term opioid treatment, including buprenorphine for addiction, cannot take it; for a short course of opioids it is paused, and lower opioid doses may be needed.
When is constipation on Contrave serious?
No bowel movement for several days with abdominal pain, distension or vomiting. That combination needs assessment rather than another laxative.
Separately, Contrave carries a boxed warning. Bupropion raises the risk of suicidal thoughts and behavior in children, adolescents and young adults. The label carries that as a boxed warning and tells prescribers to watch for mood changes, particularly in the first months and after any dose change.
Other reactions on Contrave's label with a page of their own
Would switching drugs help?
Constipation is on 12 of the 13 FDA labels tracked here, so the other labels are worth reading before assuming a switch avoids it. What a switch does change is what you pay, and Contrave is $99 a month at the maintenance dose here.
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The listing, the schedule and the warnings are read from FDA prescribing information for CONTRAVE, published 2025-11-17; the notes on why it happens and what helps are general guidance, not label text. Information only, not medical advice — a symptom that worries you is a call to your prescriber, not a search result.