Semaglutide
Bottom line
The same substance costs $178 a month at its cheapest verified route and $548 at its dearest — 3.1 times as much, a gap of $370 a month or $4,440 a year. Which product it is sold as changes the approved indication and the dose ceiling, not the molecule.
Last updated 2026-06-10 — every published price for this molecule
What is semaglutide, and what does it cost?
Semaglutide is sold as Wegovy pill, Wegovy, Ozempic, Compounded semaglutide, Rybelsus — the same active substance under different approved indications and different dose ceilings, which is why switching between them is a prescribing decision rather than a change of medication. halfrx records 8 verified routes to it, from $178 a month at Mochi Health to $548 at Calibrate, which is 3.1 times the price for the same molecule. Each figure is the all-in maintenance price — membership plus medication where a seller bundles them — read from that seller's own published page on the date beside it. On trial evidence the best published result for this molecule is 16.6% average weight loss, from the trial behind Wegovy pill; no head-to-head has compared it against another molecule, so that ranks a published result rather than the drug. Its FDA label lists nausea, fatigue, constipation, diarrhoea, vomiting among the common reactions, each with its own page here. A compounded preparation of the same molecule is a different legal product rather than a discount on the approved one: compounding is an exemption from approval, so it carries no trial and no approved label of its own.
Every verified route, cheapest first
Products and sellers together, because the question is what the molecule costs rather than which shelf it sits on.
| Route | A month | What it is | Trial loss | Checked |
|---|---|---|---|---|
| Mochi Health | $178 | compounded, not FDA approved | — | 2026-08-19 |
| Ozempic | $199 | direct from the maker | 12% | 2026-06-10, past 45 days |
| Compounded semaglutide | $199 | compounded, not FDA approved | — | 2026-06-10, past 45 days |
| Noom Med | $249 | compounded, not FDA approved | — | 2026-08-20 |
| Wegovy | $349 | direct from the maker | 14.9% | 2026-08-19 |
| NovoCare Pharmacy | $349 | provider | — | 2026-08-27 |
| LifeMD | $368 | provider | — | 2026-08-19 |
| Calibrate | $548 | provider | — | 2026-08-19 |
The products semaglutide is sold as
1. Wegovy pill
First FDA-approved GLP-1 pill. $149 during titration; Novo does not publish what the 25 mg maintenance dose costs.
- A month
- no verified price
- Trial loss
- 16.6%
- FDA status
- FDA approved for chronic weight management
2. Wegovy
$349/mo flat across every standard dose, with no refill deadline attached. Lilly's equivalent has one.
- A month
- $349
- A first year
- $4,237
- Trial loss
- 14.9%
- FDA status
- FDA approved for chronic weight management and cardiovascular risk reduction
3. Ozempic
Same molecule as Wegovy, approved for type 2 diabetes. $199/mo through the GoodRx–Novo deal.
- A month
- $199
- Trial loss
- 12%
- FDA status
- FDA approved for type 2 diabetes. Weight loss is off-label use.
4. Compounded semaglutide
$149–$299/mo for the same molecule — and the reason it is cheap is the reason it is risky.
- A month
- $199
- Trial loss
- not published
- FDA status
- Not FDA approved. Compounded drugs are not reviewed by the FDA for safety, efficacy or quality.
5. Rybelsus
The diabetes tablet of semaglutide. Novo publishes no cash price — the $25 is a copay card, not a price.
- A month
- no verified price
- Trial loss
- not published
- FDA status
- FDA approved for type 2 diabetes. Weight loss is off-label use.
What every semaglutide label lists, and each on its own page
These reactions appear on the FDA label of Wegovy, Ozempic — the same molecule, so the same list.
- Does Wegovy make you feel sick?
- Does Wegovy make you tired?
- Does Wegovy cause constipation?
- Does Wegovy cause diarrhoea?
- Does Wegovy make you throw up?
Boxed warning. In rodents this molecule caused thyroid C-cell tumours at human-relevant doses. Whether it does so in people is unknown, and the label carries that as a boxed warning. It is contraindicated outright with a personal or family history of medullary thyroid carcinoma or MEN 2.
Savings programmes across semaglutide
- Ozempic and Wegovy cash price via GoodRx
$199 a month for Ozempic or Wegovy pens — GoodRx with Novo Nordisk
- Wegovy first-fill price
$199 a month for 0.25 mg and 0.5 mg — Novo Nordisk
- Wegovy pill titration price
$149 a month — Novo Nordisk
- Wegovy savings card
As little as $25 a month — Novo Nordisk
Semaglutide, answered
- What is the cheapest semaglutide?
- Mochi Health at $178 a month all-in once titrated, read from its own published page on 2026-08-19. The dearest verified route to the same molecule is Calibrate at $548 — 3.1 times the price for the same substance.
- Which products contain semaglutide?
- Wegovy pill, Wegovy, Ozempic, Compounded semaglutide, Rybelsus. They differ by approved indication and by dose ceiling rather than by active substance, which is why a switch between them is a prescribing decision rather than a change of medication.
- Is compounded semaglutide the same as the branded version?
- Same molecule, different legal product. Compounding is an exemption from FDA approval rather than a form of it, so a compounded preparation has no trial and no approved label of its own, and its quality is a fact about the pharmacy that mixes it. No seller on this site names that pharmacy — all eleven checked, with the pages read listed at /pharmacy.
- How much weight do people lose on semaglutide?
- 16.6% on average in the trial behind Wegovy pill, OASIS 4, phase 3: 16.6% mean weight loss on 25 mg once daily when treatment was adhered to. That figure describes one trial population under one protocol; no head-to-head trial has compared these molecules against each other, so it ranks published results rather than the drugs.
Every price is read from the seller's own published page on the date shown; anything past 45 days without a re-check is marked stale rather than quietly aging. Label information from FDA prescribing information for WEGOVY. Information only, not medical advice.