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Semaglutide

Bottom line

The same substance costs $129 a month at its cheapest verified route and $548 at its most expensive — 4.2 times as much. That is a gap of $419 a month, or $5,028 a year. Which product it is sold as changes the approved indication and the dose ceiling, not the molecule.

No clinician has reviewed this page. Label and trial statements are quoted from the FDA label or the trial cited beside them. General guidance is marked as such, and every price carries the date it was verified. That is sourcing, not medical review. What we do and do not check · Who checked the price

Last updated 2026-09-22 — every published price for this molecule. Read and dated by Alex Seot.

What is semaglutide, and what does it cost?

Semaglutide is sold as Wegovy, Wegovy pill, Ozempic, Compounded semaglutide and Rybelsus — the same active substance under different approved indications and different dose ceilings, which is why switching between them is a prescribing decision rather than a change of medication. halfrx records 11 verified routes to it, from $129 a month at Strut Health to $548 at Calibrate, which is 4.2 times the price for the same molecule. Each figure is the all-in maintenance price — membership plus medication where a seller bundles them — each with its source and the date it was read beside it. On trial evidence the best published result for this molecule is 14.9% average weight loss, from the trial behind Wegovy. That is a label figure; the trials that put it against another molecule are SURMOUNT-5 (weight fell 20.2% on tirzepatide against 13.7% on semaglutide over 72 weeks, in adults with obesity); SURPASS-2 (tirzepatide lost 1.9 to 5.5 kg more than semaglutide 1 mg over 40 weeks, in type 2 diabetes); STEP 8 (weight fell 15.8% on semaglutide 2.4 mg against 6.4% on liraglutide 3.0 mg over 68 weeks); ACHIEVE-3 (orforglipron lowered HbA1c more than oral semaglutide 7 or 14 mg over 52 weeks, in type 2 diabetes). Between them its FDA labels list nausea, fatigue, constipation, diarrhea, vomiting, hair loss, abdominal pain, indigestion, reflux, burping, bloating, dizziness, headache, decreased appetite and low blood sugar among the common reactions — not every label lists every one — each with its own page here. A compounded preparation of the same molecule is a different legal product rather than a discount on the approved one: compounding is an exemption from approval, so it carries no trial and no approved label of its own.

Where can I buy semaglutide?

Every verified route, cheapest first: products and sellers together, because the question is what the molecule costs rather than which shelf it sits on.

RouteA monthWhat it isTrial lossChecked
Strut Health$129compounded, not FDA approved—2026-09-22
Noom Med$249compounded, not FDA approved—2026-09-22
Found$289compounded, not FDA approved—2026-09-22
Henry Meds$297compounded, not FDA approved—2026-09-20
Wegovy pill$299direct from the maker13.6%2026-09-10
Medvi$299provider—2026-09-14
Wegovy$349direct from the maker14.9%2026-09-22
Ozempic$349direct from the maker6.4% (from kg)2026-09-22
NovoCare Pharmacy$349provider—2026-09-22
LifeMD$498provider—2026-09-13
Calibrate$548provider—2026-09-22

The products semaglutide is sold as

1. Wegovy

$349/mo flat across every standard dose, with no refill deadline attached. Lilly's equivalent has one.

A month
$349
A first year
$4,237
Trial loss
14.9%
FDA status
FDA approved for cardiovascular risk reduction, chronic weight management from age 12, and noncirrhotic MASH with moderate to advanced liver fibrosis at stages F2 to F3 — the last under accelerated approval, which the label says may be contingent on a confirmatory trial.

Wegovy cost →Alternatives →

2. Wegovy pill

The first GLP-1 pill approved for weight loss. NovoCare self-pay is $149 a month at 1.5 mg, $199 at 4 mg, and $299 at 9 mg and at the 25 mg dose you stay on.

A month
$299
A first year
$3,338
Trial loss
13.6%
FDA status
FDA approved for cardiovascular risk reduction in adults with established cardiovascular disease and either obesity or overweight, and for chronic weight management in adults. The tablet and the injection share one label with separate indication lists: the tablet is not approved for the MASH indication the injection carries, and not for patients under 18.

Wegovy pill cost →Alternatives →

3. Ozempic

Same molecule as Wegovy, approved for type 2 diabetes. $199 for two fills, then $349 to $499 a month.

A month
$349
A first year
$4,237
Trial loss
6.4% (from kg)
FDA status
FDA approved for type 2 diabetes: glycemic control, cardiovascular risk reduction, and kidney outcomes. Weight loss is off-label use.

Ozempic cost →Alternatives →

4. Compounded semaglutide

$129–$349/mo for the same molecule — and the reason it is cheap is the reason it is risky.

A month
no verified price
Trial loss
not published
FDA status
Not FDA approved. Compounded drugs are not reviewed by the FDA for safety, efficacy or quality.

Compounded semaglutide cost →Alternatives →

5. Rybelsus

Novo publishes no cash price for Rybelsus, and the federal TrumpRx tablet is the Ozempic pill — a different strength on the same label.

A month
no verified price
Trial loss
not published
FDA status
FDA approved for type 2 diabetes. Weight loss is off-label use.

Rybelsus cost →Alternatives →

What the semaglutide labels list, and each on its own page

Each reaction below is listed among the common adverse reactions on at least one of these FDA labels — Wegovy pill, Ozempic, Wegovy and Rybelsus. The labels do not all list the same ones, so each line names the labels that do.

Boxed warning. In rodents this molecule caused thyroid C-cell tumors at clinically relevant exposures. Whether it does so in people is unknown, and the label carries that as a boxed warning. It is contraindicated outright with a personal or family history of medullary thyroid carcinoma or MEN 2.

Savings programs across semaglutide

Every verified price, ranked →What a first year costs →Which pharmacy fills it →What the savings cards cap →When a generic can arrive →CagriSema, not yet approved →What is not approved yet →

Semaglutide, answered

What is the cheapest semaglutide?
Strut Health at $129 a month all-in once titrated, read from its own published page on 2026-09-22. The most expensive verified route to the same molecule is Calibrate at $548 — 4.2 times the price for the same substance.
Which products contain semaglutide?
Wegovy, Wegovy pill, Ozempic, Compounded semaglutide and Rybelsus. They differ by approved indication and by dose ceiling rather than by active substance, which is why a switch between them is a prescribing decision rather than a change of medication.
Is compounded semaglutide the same as the branded version?
Same molecule, different legal product. Compounding is an exemption from FDA approval rather than a form of it, so a compounded preparation has no trial and no approved label of its own, and its quality is a fact about the pharmacy that mixes it. No seller on this site names that pharmacy — all eleven checked, with the pages read listed at /pharmacy.
How much weight do people lose on semaglutide?
14.9% on average in the trial behind Wegovy, STEP 1, Study 2 on the label (NCT03548935), 68 weeks: 14.9% mean weight loss at 2.4 mg against 2.4% on placebo, intention-to-treat. That figure describes one trial population under one protocol. Against other molecules it has been tested head to head in SURMOUNT-5 (weight fell 20.2% on tirzepatide against 13.7% on semaglutide over 72 weeks, in adults with obesity); SURPASS-2 (tirzepatide lost 1.9 to 5.5 kg more than semaglutide 1 mg over 40 weeks, in type 2 diabetes); STEP 8 (weight fell 15.8% on semaglutide 2.4 mg against 6.4% on liraglutide 3.0 mg over 68 weeks); ACHIEVE-3 (orforglipron lowered HbA1c more than oral semaglutide 7 or 14 mg over 52 weeks, in type 2 diabetes).

Every price carries its source and the date it was read; anything past 45 days without a re-check is marked stale rather than quietly aging. Label information from FDA prescribing information for WEGOVY. Information only, not medical advice.

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