Does Zepbound cause constipation?

Yes, and it is on the label rather than only in reports: constipation appears among the common adverse reactions in Zepbound's FDA prescribing information, published 2026-09-02. Listed means it was seen often enough in the trials to be printed, not that it happens to everyone. The same reaction is on the label of Mounjaro too. Tirzepatide is the same molecule in all of them, so this belongs to the substance rather than the brand, and switching between them is no way out of it. The same slowed gut transit that produces the fullness produces constipation at the other end. Eating much less compounds it: less food means less fiber and less fluid, and both are what keep things moving. It clusters in the days after each dose increase. Zepbound steps up on a published schedule that reaches the maintenance dose at week 5. Most people see a few rough days after each step and a settling in between, not one long stretch. Once you are at 5 mg, 10 mg or 15 mg once weekly and no longer stepping up, the trigger stops recurring. What helps first: fluid first. It is the most common deficit and the easiest to fix. It stops being ordinary at a specific line: no bowel movement for several days with abdominal pain, distension or vomiting. That combination needs assessment rather than another laxative.