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How to inject Wegovy

Taken once weekly, on the same day each week, at any time of day, with or without meals. Everything below is quoted from the FDA label rather than summarised, because a dosing instruction restated twice stops being the label and the detail that goes missing is always the number. What this page adds to the label is the part the label has no reason to carry: what a mistake costs.

How do you inject Wegovy, and what does getting it wrong cost?

Inject WEGOVY subcutaneously in the abdomen, thigh, or upper arm. The time of day and the injection site can be changed without the need for a dosage modification. Rotate injection sites with each dose. Storage is where the money is: the label allows 28 days out of the refrigerator, counted as a total rather than a run, and past it says to discard. At the maintenance rate stored on this site that is $349 thrown away — one pen, one month. And missing doses does more than skip one: if 2 or more consecutive doses of wegovy injection are missed, reinitiate dosage escalation at a lower dosage to reduce the risk of gastrointestinal adverse reactions. On a ladder priced per dose, a restart is paid in months at the early rates rather than in a single fill.

What the label says

Where it goes

Inject WEGOVY subcutaneously in the abdomen, thigh, or upper arm. The time of day and the injection site can be changed without the need for a dosage modification.

Rotating sites

Rotate injection sites with each dose.

Before use

Store the WEGOVY prefilled single-dose pen or single-dose syringe in the refrigerator from 2°C to 8°C (36°F to 46°F).

Out of the fridge — 28 days

If needed, prior to the pen or syringe cap removal, the pen can be kept from 8°C to 30°C (46°F to 86°F) up to 28 days. Protect WEGOVY injection from light. WEGOVY injection must be kept in the original carton until use.

Freezing

Do not freeze WEGOVY and do not use if it has been frozen.

A missed dose

If one dose of WEGOVY injection is missed and the next scheduled dose is more than 2 days away, administer WEGOVY injection as soon as possible. If it is less than 2 days away, do not administer the missed dose. Resume dosing on the regularly scheduled day of the week.

Missing more than one

If 2 or more consecutive doses of WEGOVY injection are missed, reinitiate dosage escalation at a lower dosage to reduce the risk of gastrointestinal adverse reactions.

Read from FDA prescribing information for WEGOVY on 2026-08-28. Labels are revised; the date is there so you can tell how old this reading is. Information only, not medical advice — dosing is a decision for the clinician who wrote the prescription.

What a mistake costs

  • A pen left out past 28 days: $349. The label says discard it, and nothing about a partial refund follows — that is a month of medication at the maintenance rate this site stores for Wegovy.
  • A frozen box: the same $349. The label is categorical about not using it, whatever it looks like afterwards.
  • Enough missed doses to restart the escalation: paid in months, not in one fill. A first year climbing this ladder is $4,237, and a restart puts the early-dose months back in front of you.
What Wegovy costs without insurance →The full Wegovy dose schedule →

Injecting Wegovy, answered

Where do you inject Wegovy?
Inject WEGOVY subcutaneously in the abdomen, thigh, or upper arm. The time of day and the injection site can be changed without the need for a dosage modification. Rotate injection sites with each dose. That is the label's wording, not a summary of it. Nothing about the site changes the dose — the label says explicitly that the time of day and the injection site can be changed without a dosage modification.
How long can Wegovy stay out of the fridge?
28 days, and the label states it as a total rather than a run: If needed, prior to the pen or syringe cap removal, the pen can be kept from 8°C to 30°C (46°F to 86°F) up to 28 days. Protect WEGOVY injection from light. WEGOVY injection must be kept in the original carton until use. Past that the instruction is to discard, which is why this page carries a price at all — a discarded pen is $349 of medication at the maintenance rate stored here.
What if you miss a dose of Wegovy?
If one dose of WEGOVY injection is missed and the next scheduled dose is more than 2 days away, administer WEGOVY injection as soon as possible. If it is less than 2 days away, do not administer the missed dose. Resume dosing on the regularly scheduled day of the week. And the part that costs money: If 2 or more consecutive doses of WEGOVY injection are missed, reinitiate dosage escalation at a lower dosage to reduce the risk of gastrointestinal adverse reactions.
Does restarting the escalation cost more?
Yes, and not by one fill. These ladders are priced per dose, so restarting means paying the early-dose months again before reaching the maintenance rate. A first year climbing the ladder is $4,237; a restart adds the low-dose months back on top of wherever you had got to. The per-dose figures are on the cost page for this drug.

Everything on Wegovy

Last updated 2026-08-28 — the FDA label this page quotes