Does Trulicity take away your appetite?

Yes, and it is on the label rather than only in reports: decreased appetite appears among the common adverse reactions in Trulicity's FDA prescribing information, published 2026-08-10. Listed means it was seen often enough in the trials to be printed, not that it happens to everyone. Reduced appetite is the drug working rather than a side effect in the usual sense. The label lists it among the common reactions because it is measured as one, but it is the route by which every one of these medicines produces weight loss. It becomes a problem at the point where intake falls below what a body needs, which is easy to miss precisely because hunger is no longer the signal. It clusters in the days after each dose increase. Trulicity's starting dose is already a maintenance dose, so any step up after it is optional. Most people see a few rough days after each step and a settling in between, not one long stretch. Once you are at 0.75 mg to 4.5 mg once weekly and no longer stepping up, the trigger stops recurring. What helps first: writing down what you actually ate for three days. Almost nobody estimates this correctly once appetite is suppressed. It stops being ordinary at a specific line: being unable to keep food or fluid down at all, weight falling far faster than expected, or fainting. Also new hair loss with fatigue, which usually means intake has been well under for some weeks.