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What is Qsymia?

What is Qsymia, and how does it work?

Qsymia (phentermine/topiramate) is a tablet made by Vivus, whose active ingredient is phentermine and topiramate. FDA approved for chronic weight management Nobody knows, and the label says so. Both halves are approved on results rather than on a mechanism anyone has established. In its pivotal trial it produced 8.6% mean weight loss. It costs $98 a month once titrated, a figure read from the seller's own page on 2026-08-27 — the maintenance rate rather than the starting dose, because the starting dose is not the dose anyone stays on.

How it works, from the label

Nobody knows, and the label says so. Both halves are approved on results rather than on a mechanism anyone has established.

The precise mechanism of action of phentermine on weight reduction is not known. The precise mechanism of action of topiramate on weight reduction and long-term maintenance of body weight is not known. Topiramate's effect on weight reduction and long-term maintenance of body weight may be due to its effects on both appetite suppression and satiety enhancement, induced by a combination of pharmacologic effects including augmenting the activity of the neurotransmitter gamma-aminobutyrate.

Quoted from the mechanism of action section of FDA prescribing information for QSYMIA, read 2026-08-29. Not paraphrased: how a drug works is the last thing a price site should put in its own words.

What it is approved for

  • Chronic weight management

    To reduce excess body weight and maintain weight reduction long term in adults and pediatric patients aged 12 years and older with obesity, and in adults with overweight in the presence of at least one weight-related comorbid condition.

Which approval a plan cannot exclude — a weight-loss exclusion is written against the use, not the molecule.

What the trial found

8.6% of body weight. CONQUER and SEQUEL, phase 3: 6.6% to 8.6% mean weight loss at 56 weeks by dose, with 62–70% of participants losing at least 5% of body weight

One trial, one protocol, one population. Comparing it with another drug's figure compares two separate experiments rather than two drugs — the comparison, and what a point of body weight costs.

What it costs

$98 a month once titrated, read from the seller's own page on 2026-08-27. Definitional pages in this category stop before this line; it is the reason this one exists.

Qsymia price and terms →The cheapest way to get it →

Qsymia, answered

How does Qsymia work?
Nobody knows, and the label says so. Both halves are approved on results rather than on a mechanism anyone has established. The label's own words, from its mechanism of action section: "The precise mechanism of action of phentermine on weight reduction is not known. The precise mechanism of action of topiramate on weight reduction and long-term maintenance of body weight is not known. Topiramate's effect on weight reduction and long-term maintenance of body weight may be due to its effects on both appetite suppression and satiety enhancement, induced by a combination of pharmacologic effects including augmenting the activity of the neurotransmitter gamma-aminobutyrate."
What is Qsymia approved for?
chronic weight management. Approvals are quoted from the label rather than summarised, because the wording is what a prior authorisation is judged against — the full text of each is on the indications page.
How much weight did Qsymia lose in its trial?
8.6% of body weight. CONQUER and SEQUEL, phase 3: 6.6% to 8.6% mean weight loss at 56 weeks by dose, with 62–70% of participants losing at least 5% of body weight That is what one trial reported under its own protocol, not a prediction for any person, and it cannot be compared directly with another drug's figure because no trial ran them against each other.
How much does Qsymia cost?
$98 a month once titrated, read from the seller's own page on 2026-08-27. The starting dose is usually cheaper and nobody stays on it, which is why the maintenance figure is the one this site records.

Everything on Qsymia

Last updated 2026-08-29 — the FDA label this page quotes